Pittsburgh International Airport (IATA: PIT, ICAO: KPIT) is situated in the Pittsburgh suburb of Findlay Township at the future intersection of I-376 and I-576, with portions of the airport located in Moon Township. It has been a focus city for US Airways, and until 2005 was the airline's largest hub. The airport now retains the title of being US Airways's largest secondary hub.

Pittsburgh International is the second busiest passenger airport in Pennsylvania and 42nd busiest in the United States, serving 9,987,310 passengers in 2006 on 235,264 aircraft operations. Until 2004, US Airways operated a major hub at Pittsburgh International. As of 2007, the airline remains PIT's largest carrier (handling 39 percent of passengers), and the complex serves as a focus city for the airline. Southwest Airlines began service at the airport in May 2005 and is now the second largest airline in Pittsburgh with nonstop service to 7 destinations and more than 20 daily flights. Pittsburgh is also a hub for US Airways Express carriers Republic Airlines, and Trans States Airlines. The airport offers service to the United States, Canada, Mexico, and the Caribbean.